Cardiovascular Biology

המעבדה לביולוגיה קרדיווסקולרית
Head of the lab:
Ran Kornowski M.D.
Phone: 03-9377107
email: rkornowski@clalit.org.il,
Lab Manager:
Dorit Leshem-Lev Ph.D and Perl Leor M.D.
Phone: 054-7773200
email: doritl2@clalit.org.il
Research team:
  • ד"ר אלון אייזן
  • ד"ר עמנואל הררי
  • ד"ר קטיה אורבין
  • ד"ר אסנת יצחקי
  • ד"ר יעלה טלמור
  • ד"ר מאיה ויסמן
Research Areas:

Our laboratory is a part of the cardiovascular division in the Rabin Medical Center.

Coronary artery disease remains a leading cause for death. Understanding the equilibrium between endothelial injury and repair has a particular importance in cardiovascular disease. The laboratory of cardiovascular biology thus focuses on studying endothelial injury, atherosclerosis, and endothelial progenitor cell levels and function in cases of: cardiovascular diseases. 

Our research encompasses both basic science topics, mostly related to cell cultures, and clinical topics- studying different cardiovascular disease states.

The laboratory has developed several collaborative efforts, including projects with Prof. Edith Hochauser from the Cardiac Research Laboratory at Felsenstein Medical Research Institute, Prof. Dror Fixler, the head of the Institute of Nanotechnology and Advanced Materials at the Bar Ilan University, Prof. Pia Raanani and Dr. Galia Spectre from the Institute of Hematology, Davidoff Center, Beilinson Hospital and Galit Granot, from the Laboratory of Experimental Hematology at the Felsenstein Medical Research Institute. These studies utilize models of human cell cultures, imaging studies in humans and in animals, the application of gold nano-particles and other innovative methods.

Research Topics:

Endothelial progenitor cells:

1. The effect of proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors on endothelial progenitor cells.

2. Long term evaluation of endothelial progenitor cells in patient undergoing hematopoietic stem-cells translation.

3. The effect of Amyloid targeted therapies on endothelial progenitor cells.

4. Differences in endothelial progenitor cell count and function in patients suffering from myocardial infarction treated with the new-generation P2Y12 inhibitors.

Colony forming units (CFUs) of endothelial progenitor cells, after 7 days culture.

 

Platelets:

1. Reticulated platelets in patients with Takotsubo cardiomyopathy

2. Thrombin generation in patients treated with the new P2Y12 inhibitors.

3. Studies focusing on reticulated platelets in different clinical scenarios.

Atherosclerosis

1. The pathogenesis of accelerated atherosclerosis as a postulated mechanism for cardiovascular toxicity of tyrosine kinase inhibitors.

2. Gold nano-particles as detection and treatment for atherosclerotic vascular disease.

 

3. M1 and M2 macrophages and its ability to uptake gold nanoparticles.

Publications:
Contact details
Leshem Dorit Mobile: 054-7773200
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