Inflammation Research

המעבדה לחקר הדלקת
Head of the lab:
Yair Molad, M.D.
email: ymolad@clalit.org.il,
Lab Manager:
Vitaly Kliminski, Ph.D.
Phone: 054-4495903
email: vitalykl@clalit.org.il
Research team:
  • ד"ר אירנה לגובסקי
Research Areas:

Fields of Interest

The focus of the current research in our laboratory is aimed to investigate novel molecular aspects of innate immune response in autoimmunity and inflammatory diseases.

 Our primary field of interest is the role of triggering receptor expressed on myeloid cells-1 (TREM-1) in arthritis, lupus (SLE) and atherosclerosis.

We've found a novel pathway for ameliorating the LPS-induced up-regulation of macrophage membrane TREM-1 expression and enhancing TREM-1 shedding via a TLR-9-mediated pathway (Innate Immunity 19(6):623-30, 2013).

We've shown that plasma levels of soluble TREM-1 (sTREM-1) positively correlate with disease activity in patients with newly diagnosed DMARD-naïve early rheumatoid arthritis (Eur J Clin Invest 2015; 45: 557 – 564).

In another study, we've shown that plasma sTREM-1 correlate with thrombotic events in patients with the anti-phospholipid (Arthritis Res Ther2019; 21: 10).

Recently, we've shown that plasma sTREM-1 level predicts acute coronary syndrome in patients who present to the emergency department with a complaint of chest pain (submitted for publication).

We also found that urinary sTREM-1 correlated with active nephritis in lupus patients whereas its plasma level correlated with the systemic disease activity.

In our current research we use a rodent model of monosodium urate (MSU) crystal-induced arthritis and found that sTREM-1 exerts anti-inflammatory effects by decreasing PMN influx as well as inhibiting the production of TNFα, IL-8, CCL3 whereas the level of the anti-inflammatory cytokine TGFβ is not affected by sTREM-1. We also show that Syk inhibition ameliorates the pro-inflammatory effects of MSU crystals and agonist TREM-1 antibody (in vitro). We aim to determine the effect of TREM-1 on inflammasome activation. These studies may pave the road towards novel drugs for the treatment of gout (unpublished data).

Contact details
Kliminski Vitali Mobile: 054-4495903
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