Neuroendocrine Tumor

המעבדה לחקר גידולים נוירואנדוקרינים
Head of the lab:
Prof. Ilan Shimon, M.D
Phone: 03-9377182
email: ilanshi@clalit.org.il,
Lab Manager:
Phone: 03-9376780, 054-4224311
email: hadarar@clalit.org.il
Research team:
  • ד"ר עידית דותן
Students:
  • Ph.D. student: Yifat Bareli
  • Msc. student: Aseel Yunes
Research Areas:

Fields of Interest

Our goal is to elucidate the molecular mechanisms that regulate the development of special entity called neuroendocrine tumors (NETs). In this heterogeneous family of tumors, we focus mainly on pituitary, medullary thyroid, lung and pancreatic NETs. We study the expression and function of genes that may affect cell proliferation and hormone secretion and we characterize the mechanisms of action of potential therapeutic compounds. In addition to various cell lines applied, cooperation with neurosurgeons and pathologists enable us access to multiple types of human tumors. Some of our findings are depicted in the Figure. 

Current Research Topics

  • The regulation of p53 splicing by PICT-1 and its effect on the sensitivity of neuroendocrine tumor cells to Everolimus, mTOR inhibitor
  • The expression and function of Ephrin B6 in non-functioning pituitary tumors
  • Histone deacetylase inhibitors: their individual and combined effects with somatostatin analogs on PRL-secreting pituitary tumors

1. Rubinek T, Et al. JCEM, 2003

2. Rubinfeld H, Et al. Endocrinology, 2011

3. Rubinfeld H, Et al. Mol. and Cell. Endo., 2014

4. Gorshtein A, Et al. Endocrine Related Cancer, 2009

5. Rubinfeld H, Et al. Neuroendocrinology, 2016

6. In progress

7. Ozeri O, Et al. Pituitary, 2019

8. Shahmoon S, Et al. Am J Physiol Endocrinol Metab, 2014

9. Rubinek T, Et al. Endocrine, 2005

10. Rubinfeld H, Et al. European J of Endocrinology, 2004

11. Rubinfeld H, Et al. JCEM, 2006

 

Contact details
Robinfeld Hadara Mobile: 054-4224311
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