of Interest & Research Topics
There is increasing evidence supporting a link between
development of metabolic disorders (diabetes and obesity) and cognitive
dysfunctions associated with impaired brain insulin signaling. The most common
type of dementia is Alzheimer's disease, which is often associated with brain
insulin resistance and deficiency. There is currently no cure for Alzheimer's
disease, and although symptomatic treatments are available, they have many
For many years, the laboratory team was involved in the
development of bio-artificial pancreas for treatment of type 1 diabetes.
Bio-artificial pancreas is an implanted device that contains immunoisolated pancreatic
islets, functioning like a real pancreas to release insulin and control blood glucose.
The main limitation of this approach is insufficient oxygen supply to
immunoisolated islets. To improve islet oxygenation, we developed proprietary
photosynthetic oxygen generator for bio-artificial pancreas (Fig.1).
In collaboration with the Laboratory of Biological
Psychiatry (Head Prof. Avi Weizman), we recently established a new rat model of
sporadic Alzheimer's disease-like dementia associated with brain insulin
resistance and obesity-related metabolic dysfunctions such as hyperinsulinemia,
hyperleptinemia and fatty liver (Fig. 2). In order to attenuate cognitive and
peripheral metabolic dysfunctions, we developed islet-based technology for
insulin delivery to the brain (Fig. 3). Our results demonstrate that islet
transplantation into cranial subarachnoid cavity may be used as a promising
tool for treatment of Alzheimer's disease dementia associated with peripheral