The Center for
translational research in head and neck cancer and skull-base tumors at Rabin
Medical Center, which is a leading center in these fields at the national
level, aims to promote the treatment and improve the quality of life of
patients through basic and translational research.
practices a "personalized medicine" approach that includes genetic
characterization of tumors and optimization of treatment, while reducing side
The laboratory has
a tissue biobank, which is the basis for performing studies both in tissue
cultures as well as animal models in order to understand the genetics and
biology of these tumors and their resistance mechanisms to radiation and
chemotherapy. Furthermore, we explore different strategies to overcome these
mechanisms and try to develop new therapeutic approaches with the potential to
advance to clinical trials. In addition, we conducted studies to explore the
role of the immune system in head and neck and skull base tumors by integrating
Another aspect of
research in the lab is the mechanism of treatment-related side effects and
their long-term implications in cancer survivors, including radiation and
chemotherapy. We aim is to develop methods for preventing or reducing these
phenomena and improve patients' quality of life.
The laboratory is
located at the Feldstein Medical Research Center and operates in conjunction
with the Head and Neck Oncology Unit at the Davidoff Cancer Center.
research projects in the lab are:
- Overcoming acquired resistance to PI3K inhibitors
in head and neck squamous cell carcinoma.
- Activation and inhibition of the opiates receptor
and the effect on response to treatment in head and neck squamous cell carcinoma.
- Radiation induced salivary gland injury;
understanding the mechanism and exploring ways to mitigate the effect.